Dr. James Parkinson first described the shaking palsy in 1817 a collection of symptoms that we now call Parkinson's disease. Now some 200 years later this disease that affects one million Americans still has not been cured.
There are some treatments such as L-dopa and surgeries such as deep brain stimulation that help manage the symptoms, but all attempts to stop or reverse the disease have failed.
There is new research on a simple protein alpha-synuclein that points to a possible break through.
The working theory is that alpha-synuclein forms sticky clumps called amyloid that jump from brain cells to brain cell killing cells. This is particularly true for nerve cells that make the neural transmitter dopamine. When 70% of these dopamine cells are destroyed the patient starts displaying the symptoms of Parkinson's disease.
Researchers are working on a number of alpha-synuclein busting agents. Several of them will begin clinical trials in the next few years. If given early enough such agents might prevent the development of Parkinson's disease. Of course this treatment may not pan out, but that is the natural course of research. Never the less it is an exciting concept. We will give you updates as they develop.
There are some treatments such as L-dopa and surgeries such as deep brain stimulation that help manage the symptoms, but all attempts to stop or reverse the disease have failed.
There is new research on a simple protein alpha-synuclein that points to a possible break through.
The working theory is that alpha-synuclein forms sticky clumps called amyloid that jump from brain cells to brain cell killing cells. This is particularly true for nerve cells that make the neural transmitter dopamine. When 70% of these dopamine cells are destroyed the patient starts displaying the symptoms of Parkinson's disease.
Researchers are working on a number of alpha-synuclein busting agents. Several of them will begin clinical trials in the next few years. If given early enough such agents might prevent the development of Parkinson's disease. Of course this treatment may not pan out, but that is the natural course of research. Never the less it is an exciting concept. We will give you updates as they develop.
I am a 51 year old female that just found out I have Parkinson's, but I have been having signs of it for years, tremors, depression, body weakness. ECT. I honestly don't think my doctor was reading the signs because of my gender and age. A few years ago I had my shoulder lock up on me and I was sent to a P.T since x-rays didn't show any physical damage. My shaking was getting worse and I began falling. Only when my speech became so bad that it brought concern to my dentist was Parkinson's even considered. He phoned my doctor with his concerns about my shaking and balance problems. By this time I was forgoing shots in the back of my neck for back and neck pain to which once again I was sent to a P.T (although x-rays showed no damage) I was told I had a few spurs which were most likely causing the pain. Here I was feeling like my whole body was falling apart and doctor could not find anything wrong, maybe in was all in my head? My doctor even seemed annoyed with me and things just kept progressing and I just kept it to myself, why bother going through testing and them finding nothing? Well, it was after my second P.T called my doctor about the weakness in my legs and arms, by this time I have developed a gait in my walk and I fell more frequently. Only then did my doctor send me to a specialist and it was found that I had Parkinson's, and that I have had it for awhile. I think because I was a woman that my signs and symptoms weren't taken seriously and therefor left untreated for so long,I was taking pramipexole dihydrochloride three times daily, I Was on carbidopa levodopa but only lasted 90 minutes then wore off.I found that none of the current medications worked effective for me.I got tired of using those medication so I decided to apply natural herbs formula that was prescribed to me by my second P.T, i purchase the herbal formula from totalcureherbsfoundation. com, There has been huge progression ever since I start the treatment plan which will last for 15 weeks usage.all the symptoms and sign has begin to disappear .
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